A celiac sufferer is someone who experiences serious physical and emotional reactions when they eat foods containing gluten. Their bodies cannot tolerate gluten and never will. The only known celiac disease treatment is a celiac disease diet - a lifetime diet that is free of gluten.

Several blood tests exist for Celiac disease. They have varying degrees of accuracy. Some are more sensitive, meaning they will be positive in milder forms of the disease but are not specific, meaning a positive test may not indicate Celiac disease. Others are felt to be very specific, meaning that when they are positive, it is almost certain you have the disease.

The most specific tests are tests for Celiac disease endomysial antibodies (EMA) and
tissue transglutaminase antibody (tTG) tests. These two tests are IgA based tests and can be negative if you are deficient in the immunoglobin IgA, which occurs in 10-20% of people with Celiac. When either EMA or tTG are positive Celiac disease is very likely and usually the intestine biopsy is positive.

Types of Celiac Disease

Celiac disease has now been categorized into 4 main classes according to the NIH consensus conference.

Classical celiac disease includes those symptoms commonly associated with the disease in the past, diarrhea, bloating, abdominal pain, and weight loss.

Celiac disease with atypical symptoms includes those extra intestinal symptoms of osteoporosis, neurological involvement, and little or no abdominal symptoms.

Silent celiac disease includes those individuals who are asymptomatic yet have both positive serology and biopsy.

Latent celiac disease includes positive serology and negative biopsy, but may later present with positive symptoms or intestinal changes.

Celiac Disease Causes

Research says that the actual cause is still unknown. There is new research that indicates that celiac disease is strongly associated with a group of genes on Chromosome 6. These genes (HLA class II antigens) are involved in the regulation of the body's immune response to the gluten protein fractions. So this information shows that it may be genetic. With Celiac disease, there is a certain protein known as "gluten" that has been shown to be the trigger. Gluten is the common name given to the specific proteins in some cereal grains that are harmful to people facing celiac disease. When the gluten is broken down inside the intestine, gluten peptides that bind to HLA-DQ8 or HLA-DQ2 trigger an inflammatory T cell response.

The gluten proteins make up about 80% of the proteins that make up the inside portion of the following prohibited grains

wheat

rye

barley

triticale

The ways for a Celiac Disease Test to be taken is:

1. Through a blood test - A person with this kind of disease is a person with high levels of auto antibodies than normal which is why the villi is destroyed as they attack it by reaction to the gluten.

2. Through Undergoing an Intestinal Biopsy - An endoscope will be slowly entered into the body of a person with the disease through the mouth by a doctor who will set tools through the tube and take a piece of the small intestine to check for damaged villi.

3. Through a Dermatitis Herpetiformis test - Checking for DH in a person with Celiac Disease is a common way of searching for any possible chances of a person having CD as it is fact that some people who have DH have Celiac Disease.

4.Through Screening - Doctors test the blood for auto antibodies in the blood in people who sometimes don't show symptoms to determine the severity of the disease or if the person has the disease if ever. It can trace it if it is found to be hereditary.


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